Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE
نویسندگان
چکیده
منابع مشابه
DrICE resurrects Grim to antagonize DIAP1
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The inhibitor of apoptosis protein DIAP1 suppresses apoptosis in Drosophila, with the second BIR domain (BIR2) playing an important role. Three proteins, Hid, Grim, and Reaper, promote apoptosis, in part by binding to DIAP1 through their conserved N-terminal sequences. The crystal structures of DIAP1-BIR2 by itself and in complex with the N-terminal peptides from Hid and Grim reveal that these ...
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NF-κB pathways are key signaling cascades of the Drosophila innate immune response. One of them, the Immune Deficiency (IMD) pathway, is under a very tight negative control. Although molecular brakes exist at each step of this signaling module from ligand availability to transcriptional regulation, it remains unknown whether repressors act in the same cells or tissues and if not, what is ration...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2011
ISSN: 2041-1723
DOI: 10.1038/ncomms1418